These are papers related to the Palner Lab, for a complete list of papers by Mikael Palner please see ORCID or Pure at SDU
Current Preprints
Gudmundsen, F., Li, Z., Baun, C., Svensson, J.E., Langkjær, N., Palner, M., Plavén-Sigray, P., 2025, Single-dose rapamycin increases brain glucose metabolism but reduces synaptic density in Long-Evans rats: A PET imaging study. BioRxiv 2026.
https://doi.org/10.1101/2025.03.11.642549
Siddiqi, F.H., Raval N.R., Palner, M., Nielsen, J.E., Pocock, R., Rubinsztein, D.C., Ejlerskov, P., 2025. Tbc1d15 knockdown in vivo alleviates α-synuclein-induced neurotoxicity by promoting autophagy. BioRxiv 2026.
https://doi.org/10.1101/2024.10.01.616109
Cohen, J., Reichelt, A.C., Zamyadi, R., Roberts, G., Hardy, S., Fernandes B., Rhind S., Lewis, E.C., Bhat, V., Palner, M., Jetly, R., Dunkley, B., Ketamine-Assisted Therapy for Generalized Anxiety Disorder: A Comprehensive Case Report with Integrated Neurophysiological Imaging using Magnetoencephalography. MedRxiv 2026.
https://doi.org/10.1101/2025.02.25.25322463
Bralic, N., Bragagnolo, E., & Palner, M. Serotonergic Psychedelics as a Potential Therapeutic Strategy for Anxiety, A Systematic Review. PsyArXiv 2026.
https://doi.org/10.31234/osf.io/gf7bq_v1
Cohen, J., Parbo, P., Ørskov, P. T., Wildgruber, D., Kreifelts, B., kirk, u., … Palner, M. (2026, May 14). Low doses of psilocybin as adjunct pharmacological treatment to virtual reality exposure therapy for social anxiety disorder: A study protocol for a double-blind randomized controlled trial. PsyArXiv 2026
https://doi.org/10.31234/osf.io/3b9fx_v1
Peer-Reviewed Publications
2026
Gudmundsen F, Czurylo J, Rijsketic DR, Vo CT, Fortunato J, Jessen NS, Woodruff S, Baun C, Herth MM, Shalgunov V, Heifets BD, Fisher PM, Palner M. Serotonergic psychedelics induce distinct patterns of metabolic activity and covariance within biologically informed rat brain networks. Nat Commun. 2026 doi: 10.1038/s41467-026-75890-0.
Gregersen AT, Whelan T, Golden C, Blackmore T, Palner M. Computational Analysis of Psilocybin Effects on Three-Choice Touchscreen Reversal Learning in Rats: A Pilot Study. Psychedelic Medicine. 2026. doi: 10.1177/28314425251386879
Drange S, Cohen J, Johansen SS, Dunkley B, Palner M. Case Report: Repeated low doses of psilocybin reduce perceived symptom severity but fail to restore cognitive flexibility in a case of severe obsessive-compulsive disorder: an observational case study of identical twins. Front Psychiatry. 2026 doi: 10.3389/fpsyt.2026.1819962.
Palner M, Kolesnik E, Baun C, Poetzsch SN, Cumming P. N,N-dimethyltryptamine (DMT) is neither formed nor retained in serotonin terminals in the rat brain. Neuropharmacology. 2026 doi: 10.1016/j.neuropharm.2026.110874.
2024
Fernandes EFA, Palner M, Raval NR, Jeppesen TE, Danková D, Bærentzen SL, … Strømgaard K. Development of Peptide-Based Probes for Molecular Imaging of the Postsynaptic Density in the Brain. J Med Chem. 2024
2023
Meneghetti M, Gudmundsen F, Jessen NS, Sui K, Baun C, Palner M*, Markos C*. Mapping whole brain effects of infrared neural stimulation with positron emission tomography. Imaging Neuroscience 2023
*Shared senior authorship
Shalgunov V, Lopes van den Broek S, Vang Andersen I, García Vázquez R, Raval NR, Palner M, … Herth MM, Pretargeted imaging beyond the blood-brain barrier. RSC Med Chem 2023
Cameron LP, Benetatos J, Lewis V, Bonniwell EM, Jaster AM, … Palner M, Aguilar-Valles A. Beyond the 5-HT2A Receptor: Classic and Nonclassic Targets of Psychedelic Drug Action, Journal of Neuroscience, 2023
Kiilerich KF, Lorenz J, Scharff MB, Speth N, Xiong M, Jessen NS, … Palner M. Repeated low doses of psilocybin increase resilience to stress, lower compulsive actions, and strengthen cortical connections to the paraventricular thalamic nucleus in rats, Molecular Psychiatry, 2023.
Egger K, Gudmundsen F, Jessen NS, Baun C, Pötzsch S, Shalgunov V, … Palner M. Pharmacokinetic and Pharmacodynamic Interaction of the Ayahuasca Constituents Harmine and Dimethyltryptamine (DMT) in the Rat Brain, Frontiers of Neuropharmacology, 2023.
2022
Casado-Sainz A, Gudmundsen F, Baerentzen SL, Lange D, Ringsted A, Martinez-Tajada I, … Palner M. Dorsal striatal dopamine induces fronto-cortical hypoactivity and attenuates anxiety and compulsive behaviors in rats, Neuropsychopharmacology, 2022, 47(2) 454-464
Zhao X, Meyers KT, Marballi KK, Maple AM, Kang P, Palner, M, Overgaard A, Gallitano AL. Environment rapidly upregulates serotonin 2A receptor expression via immediate early gene Egr3. Molecular Psychiatry, 2022, 27(3).
2021
Raval NR, Gudmundsen F, Videbæk A, Petersen IN, … Palner M. Synaptic density and neuronal metabolic function measured by PET in the unilateral 6-OHDA rat model of Parkinson’s disease, Accepted Frontiers of Synaptic Neuroscience, 2021 (13),
Cumming P, Scheidegger M, Dornbierer D, Palner M, Quednow BB, Martin-Soelch C. Molecular and functional imaging studies of hallucinogenic drug action in animals and humans. Molecules, 2021, 26 (9).
Breusova K, Ernstsen KG, Palner M, Linnet K, Kristensen JL, Kretschmann AC. A quantitative method for the selective 5-HT2A agonist 25CN-NBOH in rat plasma and brain. Journal of Pharmaceutical and Biomedical Analysis, 2021, 114016
Jacobsen SC, Speth NR, Xiong M, Herth MM, Kristensen JL, Palner M, Janfelt C. Desorption Electrospray Ionization Mass Spectrometry Imaging of Cimbi-36, a 5-HT 2A Receptor Agonist, with Direct Comparison to Autoradiography and Positron Emission Tomography. Molecular Imaging and Biology, 2021.
2020
Shalgunov V, Xiong M, L’Estrade ET, Raval NR, Andersen IV, Edgar FG, Speth NR, Baerentzen SL, Hansen HD, Donovan LL, Nasser A, Peitersen ST, Kjaer A, Knudsen GM, Syvänen S, Palner M, Herth MM. Blocking of efflux transporters in rats improves translational validation of brain radioligands. EJNMMI research, 2020, 10 (1), 1-11
Jensen AA, Halberstadt AL, Märcher-Rørsted E, Odland AU, Chatha M, Speth N, Liebscher G, Hansen M, Bräuner-Osborne H, Palner M, Andreasen JT, Kristensen JL. The selective 5-HT2A receptor agonist 25CN-NBOH: structure-activity relationship, in vivo pharmacology, and in vitro and ex vivo binding characteristics of [3H] 25CN-NBOH. Biochem. Parmacol, 2020, 177:113979.
These are papers related to the Palner Lab, for a complete list of papers by Mikael Palner please see ORCID or Pure at SDU
